Volume IV, Issue 7: April 2012


Study shows improved care for O.C. stroke patients

Dr. Steven C. Cramer
"This marks an enormous improvement in the level of stroke care for Orange County residents," said study leader Dr. Steven C. Cramer.

The number of Orange County residents who get the highest level of care for stroke symptoms has increased to 20 percent since the adoption of a countywide stroke-neurology receiving center system in 2009, according to a study in the American Heart Association journal Stroke. "One in five patients who suffered an ischemic stroke were given the clot-busting drug tPA in time to reverse or reduce the stroke's effects," said lead author Dr. Steven C. Cramer, a UCI stroke neurologist. Nationally, only 3 to 5 percent of patients receive tPA in time, he noted. Ischemic stroke, in which part of the brain is deprived of oxygen due to a blood clot, is the most common form of the condition.

Stroke care system »

How salmonella resists the body's immune response

Manuela Raffatellu
Manuela Raffatellu, assistant professor of microbiology & molecular genetics

UCI researchers have discovered how salmonella, a bacterium found in contaminated raw food that causes major gastrointestinal distress in humans, thrives in the digestive tract despite the immune system's best efforts to destroy it. Their findings help explain why salmonella is difficult to eradicate and point to new treatment approaches. Most people infected with salmonella experience diarrhea, fever and abdominal cramps for up to seven days. Lead researcher Manuela Raffatellu, a UCI assistant professor of microbiology & molecular genetics, and colleagues identified a novel molecular mechanism that allows salmonella to survive.

Salmonella study »

Circadian rhythms influence metabolic output

Paolo Sassone-Corsi
Study author Paolo Sassone-Corsi is a leading expert on circadian rhythms.

By analyzing the hundreds of metabolic products present in the liver, researchers with UCI's Center for Epigenetics & Metabolism have discovered that circadian rhythms — our own body clock — greatly control the production of such key building blocks as amino acids, carbohydrates and lipids. They identified more than 600 liver-originated metabolites, which are the chemical substances created by metabolism that sustain and promote cell health and growth. Approximately 60 percent of these metabolites were found to be dependent on the endogenous circadian clock — many more than expected, as only about 15 percent of the body's genes are regulated by it.

Influence of circadian rhythms »